CBD Possible Side Effects and Free Drug Interaction Service

Research has proven the medicinal benefits of CBD Oil, but there are some interactions. Always consult your physician.

Drug Interaction Checker  

Click on ‘Drug Interaction Checker’ to be directed to site. Register for free and begin entering the medication and a list will appear for selection. Must type entry because copy and paste will not work. This free online drug interaction checker is offered by Medscape, a leading online global destination for physicians and healthcare professionals worldwide, offering the latest medical news and expert perspectives with essential point-of-care drug and disease information and relevant professional education and CME.

The European Journal of Internal Medicine published a new report in 2018 on Cannabis Drug interactions:

Most drug interactions are associated with concurrent use of other CNS depressants with cannabis. Clinically, significant drug interactions have proven rare [7], and there is no drug that cannot be used with cannabis, if necessary. THC is oxidised by (CYP) 2C9, 2C19, and 3A4. Therefore, serum levels may increase with inhibitors, or decrease with enzyme inducers. Pertinent drug interaction studies are few [45][46]. Existing studies have not demonstrated toxicity/ loss of effect of concomitant medications, but still theoretically possible [47]. One exception is high dose CBD with clobazam, wherein high levels of a sedating metabolite, N-desmethyl clobazam will require a dose reduction for that drug [29].

Journal of Current Drug Safety on Cannabis’ Possible Side Effects and Drug Interactions

Several key items of interest from the scholarly research found in the above article are listed below:

·         Cotton-Mouth

High doses of CBD can produce dry mouth, commonly called cotton-mouth due to the CB1 and CB2 receptors responding with inhibited saliva production. Drink water to solve.

·         High Doses of CBD and tremors in Parkinson’s patients

High doses may increase tremors in Parkinson’s patients. Low doses may improve tremors. Always consult a physician for proper dosage.

·         Low blood pressure

A small drop of blood pressure a few minutes after dosing may accompany high doses of CBD oil. Lightheadedness may be a symptom of the drop in blood pressure. Always consult a physician for proper dosage.

·         Hepatic Drug Inhibition involving metabolism

The liver enzyme, P450, may be inhibited from CBD. Enzymes metabolize almost 60% of synthetic or pharmaceutical or prescribed drugs, however one desires to label them. With extremely high doses of CBD, this can temporarily neutralize P450 enzymes and effect drug metabolization.

CBD can regulate blood pressure significantly, so a physician should be consulted to justify HBP medication dosage.

Consider also that highly acidic foods, like lemons or grapefruit also modifies metabolism of both CBD and P450 liver enzymes. It is not prescribed drugs alone that alter metabolism. A physician should always be consulted, especially for epilepsy patients taking clobazam in order to administer correct dosage levels.

·         Drowsiness and Alertness

Do not operate machinery or drive with higher doses of CBD as one may become drowsy. May be an effective sleep aid and restore natural circadian sleep cycle.

The majority of cases claim that CBD in low doses creates alertness.


MacCallum, Caroline A., and Ethan B. Russo. “Practical Considerations in Medical Cannabis Administration and Dosing.” European Journal of Internal Medicine, vol. 49, 2018, pp. 12-19.

It is not wise to use a product without full transparency. Insist on a verifiable full profile COA with any hemp product. Identify the testing lab with a header on the lab work. Do not accept a lab report without identifying language and contact information. Identify that COA with a correlating batch number.

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