Rub it in! Skin is the largest CB1 receptor and cannabinoids are its best friend. Rub it in!
This scientific research examines three patient cases with opioid-reduced rates with Topical Medical Cannabis – and reports a hopeful outcome. It relays that THC and CBD’s many strains and terpenes work together for effectiveness.
“The opioid-sparing effect observed in this case report cannot be overemphasized in view of the current global crisis related to opioid overuse and accidental deaths from overdoses.22Thus, any measures that can improve analgesic outcomes while reducing opioid utilization should be strongly considered” (Maida, Vincent, Corban).
“In summary, this is the first case series to demonstrate the potential for TMC to provide effective analgesia that was opioid sparing in the setting of PG. The rapid onset of analgesia after topical application suggests that the effects were mediated through absorption of the cannabinoids THC and CBD that subsequently interacted with cannabinoid receptors expressed on peripheral nociceptors and immune cells. The authors recognize the limitations of the small sample used in this preliminary investigation, which limits the evaluation of efficacy and safety. However, the promising reported findings indicate that TMC warrants further investigation through large and controlled trials in PG and all other wound classes (Maida, Vincent, Corban).
- Maida, Vincent, and Jason Corban. “Topical Medical Cannabis: A New Treatment for Wound Pain—Three Cases of Pyoderma Gangrenosum.” Journal of Pain and Symptom Management, vol. 54, no. 5, 2017, pp. 732-736.