CBD Class 2: Introduction to Terpenes – A dash of science and a plate of goodness on terpenes in cannabis.

Wallow, wiggle and writhe in delight! Terpenes, oh, terpenes, my tongue tingles electric with LIFE.

Terpene analytes are critically important because they are not inhibited by any transference system in the body. Terpenes are most beneficial in a raw state.

According to Christelle Andre, et. al., author of “Cannabis sativa: The Plant of the Thousand and One Molecules,” Terpenes are lipophilic compounds that easily cross membranes and the blood-brain barrier in particular (Fukumoto et al., 2006).

Terpenes present a wide-array of pharmacological properties, which have recently been described in several reviews (Russo, 2011Singh and Sharma, 2015).

The biological activities of D-limonene, also commonly found in Citrus essential oils, have been well described in the literature. It notably exhibits potent anti-cancer, anxiolytic and immunostimulating properties in humans (Komori et al., 1995).

β-myrcene, a terpene commonly found in hop, is recognized as a potent anti-inflammatory, analgesic, and anxiolytic component (Cleemput et al., 2009).

α-Pinene is an acetylcholinesteral inhibitor, and may thereby aid memory abilities (Kennedy et al., 2011), which could counteract the memory deficits induced by THC.

Linalool, commonly found in Lavandula angustifolia, possesses similar properties to the ones described for its monoterpene counterparts, i.e., analgesic, anti-anxiety, anti-inflammatory, and anticonvulsant (Russo, 2011).

β-caryophyllene, a well-known active principle of black pepper and Copaiba balsam, possesses potent anti-inflammatory and gastric cytoprotector activities (Singh and Sharma, 2015).

Interestingly, it selectively binds to the CB2 receptor and could therefore technically be considered as a phytocannabinoid (Gertsch et al., 2008). Pentacyclic triterpenes such as β-amyrin and cycloartenol have been shown to possess numerous biological activities including anti-bacterial, anti-fungal, anti-inflammatory and anti-cancer properties (Vázquez et al., 2012Moses et al., 2013). These triterpenes are key contributors to the pharmacological properties of numerous medicinal herbs (Kirby et al., 2008Yadav et al., 2010Sawai and Saito, 2011)

Terpenes are the natural vors, and in cannabis, each strain develops a distinct profile of terpenes. These fragrant molecules are secreted in the same oils as cannabinoids, but they are non-psychoactive, and many offer therapeutic benefits of their own.





References

Andre, Christelle M et al. “Cannabis sativa: The Plant of the Thousand and One Molecules” Frontiers in plant science vol. 7 19. 4 Feb. 2016, doi:10.3389/fpls.2016.00019

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